Enhance your Ophthalmology knowledge with next 40 MCQ for Development of Eyeball (Q41–80), covering eyelid, conjunctiva, lacrimal system, iris, ciliary body, lens, optic fissure closure, vitreous, postnatal eye development, and genetic control (PAX6, SOX2, MITF, FOXC1, PITX2). Perfect for NEET PG, AIIMS, optometrist exams, and eye anatomy exam preparation. Practice essential eye embryology MCQs for better retention and exam success. visit our ophthalmology and optometry Mcq page to explore Topic wise mcq.
Eyelids, Conjunctiva & Lacrimal System
41. Conjunctival epithelium develops from:
A. Surface ectoderm
B. Neuroectoderm
C. Mesoderm
D. Neural crest
View Answer
A. Surface ectoderm ✅ Exp: Conjunctival epithelium is ectodermal.
42. Meibomian glands develop from:
A. Modified sebaceous glands of ectoderm
B. Neural crest cells
C. Mesodermal core
D. Neuroectoderm
View Answer
A. Modified sebaceous glands of ectoderm ✅ Exp: Ectodermal in origin.
43. Glands of Zeis are:
A. Sebaceous glands
B. Sweat glands
C. Modified lacrimal glands
D. Apocrine glands
View Answer
A. Sebaceous glands ✅ Exp: Zeis = sebaceous glands associated with eyelashes.
44. Glands of Moll are:
A. Modified sweat glands
B. Sebaceous glands
C. Lacrimal glands
D. Serous glands
View Answer
A. Modified sweat glands ✅ Exp: Moll = apocrine sweat glands at eyelid margin.
45. Nasolacrimal duct develops from:
A. Surface ectoderm invagination
B. Neural crest
C. Mesodermal core
D. Neuroectoderm
View Answer
A. Surface ectoderm invagination ✅ Exp: Formed from ectodermal cord between maxillary & lateral nasal processes.
Iris, Ciliary Body & Pupil
46. Iris muscles (sphincter & dilator pupillae) develop from:
A. Neuroectoderm
B. Neural crest
C. Mesoderm
D. Surface ectoderm
View Answer
A. Neuroectoderm ✅ Exp: They are neuroectodermal (rare exception for smooth muscle).
47. Iris stroma develops from:
A. Neural crest cells
B. Neuroectoderm
C. Mesoderm only
D. Surface ectoderm
View Answer
A. Neural crest cells ✅ Exp: Stroma & melanocytes from neural crest.
48. Pupillary membrane develops from:
A. Mesodermal mesenchyme
B. Surface ectoderm
C. Neural crest
D. Retina
View Answer
A. Mesodermal mesenchyme ✅ Exp: Transient vascular membrane in front of lens.
49. Persistence of pupillary membrane →
A. Small remnants visible as strands
B. Total blindness
C. Aniridia
D. Microcornea
View Answer
A. Small remnants visible as strands ✅ Exp: Commonly leaves fine iris strands.
50. Ciliary body epithelium origin:
A. Neuroectoderm (from optic cup)
B. Neural crest
C. Surface ectoderm
D. Mesoderm
View answer
A. Neuroectoderm (from optic cup) ✅ Exp: Both pigmented and non-pigmented epithelia are neuroectodermal.
Orbit & Supporting Structures
51. Bony orbit derived from:
A. Neural crest + mesoderm
B. Neuroectoderm only
C. Surface ectoderm
D. Endoderm
View Answer
A. Neural crest + mesoderm ✅ Exp: Orbit bones from mesenchyme (crest + mesoderm).
52. Extraocular muscles develop from:
A. Preotic mesoderm
B. Surface ectoderm
C. Neural crest
D. Neuroectoderm
View Answer
A. Preotic mesoderm ✅ Exp: Classic derivation of EOMs.
53. Tenon’s capsule develops from:
A. Mesenchyme
B. Neuroectoderm
C. Surface ectoderm
D. Endoderm
View Answer
A. Mesenchyme ✅ Exp: Fibrous sheath around globe from mesenchymal tissue.
54. Orbital fat derived from:
A. Mesenchyme
B. Surface ectoderm
C. Neuroectoderm
D. Neural crest
View Answer
A. Mesenchyme ✅ Exp: Fat pads mesenchymal in origin.
55. Lacrimal sac develops from:
A. Surface ectoderm cord
B. Neural crest
C. Mesoderm
D. Neuroectoderm
View Answer
A. Surface ectoderm cord ✅ Exp: Part of nasolacrimal system, ectodermal.
56. Lens placode appears in:
A. 4th week
B. 6th week
C. 8th week
D. 10th week
View Answer
A. 4th week ✅ Exp: Ectodermal thickening appears in week 4.
57. Closure of embryonic fissure:
A. 5th–6th week
B. 3rd week
C. 8th week
D. Birth
View Answer
A. 5th–6th week ✅ Exp: Closure occurs during weeks 5–6.
58. Hyaloid artery regresses by:
A. Birth
B. 6 months postnatal
C. 1 year
D. 3 months
View Answer
A. Birth ✅ Exp: Normally gone before birth.
59. Eyelid fusion occurs at:
A. 2nd month
B. 4th month
C. 6th month
D. Birth
View Answer
A. 2nd month ✅ Exp: Eyelids fuse in 2nd month.
60. Eyelid reopening:
A. 5th month
B. 6th month
C. Birth
D. 3rd month
View Answer
B. 6th month ✅ Exp: Eyelids reopen ~6th month gestation.
61. Congenital anophthalmia is due to:
A. Failure of optic vesicle formation
B. Non-closure of optic fissure
C. Failure of lens induction
D. Neural crest defect
View Answer
A. Failure of optic vesicle formation ✅ Exp: No optic vesicle = no eye.
62. Microphthalmia is due to:
A. Arrested growth of optic vesicle
B. Persistent pupillary membrane
C. Lens coloboma
D. Eyelid fusion failure
View Answer
A. Arrested growth of optic vesicle ✅ Exp: Small malformed eye.
63. Coloboma results from:
A. Failure of closure of embryonic fissure
B. Failure of lens vesicle separation
C. Persistence of pupillary membrane
D. Arrested foveal development
View Answer
A. Failure of closure of embryonic fissure ✅ Exp: Typical coloboma occurs inferiorly.
64. Persistent hyperplastic primary vitreous (PHPV) is due to:
A. Persistence of hyaloid system
B. Closure defect
C. Optic nerve agenesis
D. Retinal dysplasia
View Answer
A. Persistence of hyaloid system ✅ Exp: Hyaloid fails to regress.
65. Cyclopia results from:
A. Failure of division of forebrain (holoprosencephaly)
B. Non-closure of fissure
C. Persistent pupillary membrane
D. Coloboma
View Answer
A. Failure of division of forebrain (holoprosencephaly) ✅ Exp: Midline defect causes single eye.
Genetics & Molecular Control
66. PAX6 gene is master gene for:
A. Eye development
B. Lens only
C. Retina only
D. Cornea only
View Answer
A. Eye development ✅ Exp: PAX6 regulates overall eye morphogenesis.
67. SOX2 mutation may cause:
A. Anophthalmia
B. Aniridia
C. Coloboma
D. PHPV
View Answer
A. Anophthalmia ✅ Exp: SOX2 critical for optic vesicle development.
68. MITF gene mutation leads to:
A. Albinism (ocular albinism)
B. Coloboma
C. Anophthalmia
D. Glaucoma
View Answer
A. Albinism (ocular albinism) ✅ Exp: MITF affects pigment development.
69. FOXC1 mutation associated with:
A. Axenfeld–Rieger anomaly
B. Aniridia
C. Retinoblastoma
D. Microcornea
View Answer
A. Axenfeld–Rieger anomaly ✅ Exp: FOXC1 → anterior segment dysgenesis.
70. PITX2 gene defect leads to:
A. Axenfeld–Rieger syndrome
B. PHPV
C. Coloboma
D. Foveal hypoplasia
View Answer
A. Axenfeld–Rieger syndrome ✅ Exp: PITX2 mutations → anterior chamber anomalies.
Postnatal Development
71. Retina continues to develop until:
A. Birth
B. Several years postnatally
C. 1st year only
D. 6 months
View Answer
B. Several years postnatally ✅ Exp: Especially macular area matures up to 4 years.
72. Myelination of optic nerve completed by:
A. Birth
B. 1 year
C. 3 years
D. 6 months
View Answer
B. 1 year ✅ Exp: Optic nerve myelination completes in infancy.
73. Foveal pit fully matures at:
A. Birth
B. 4 years
C. 6 months
D. 2 years
View Answer
B. 4 years ✅ Exp: Maturation ~4 years.
74. Pupillary light reflex appears by:
A. 30 weeks gestation
B. 12 weeks
C. Birth only
D. 6 months
View Answer
A. 30 weeks gestation ✅ Exp: Reflex detectable in utero by 30 weeks.
75. Tears secretion begins at:
A. Birth
B. 3rd month postnatal
C. 6th month
D. 1 year
View Answer
B. 3rd month postnatal ✅ Exp: Functional lacrimal gland ~3 months after birth.
76. Persistent pupillary membrane is usually:
A. Benign, asymptomatic
B. Causes blindness
C. Leads to glaucoma always
D. Indicates coloboma
View Answer
A. Benign, asymptomatic ✅ Exp: Fine strands often harmless.
77. Congenital aphakia results from:
A. Failure of lens vesicle formation
B. Arrest of optic cup
C. Persistence of pupillary membrane
D. Neural crest defect
View Answer
A. Failure of lens vesicle formation ✅ Exp: Rare anomaly due to absent lens vesicle.
78. Congenital cataract results from:
A. Disturbance in lens fibre development
B. Retinal dysplasia
C. Coloboma
D. Neural crest arrest
View Answer
A. Disturbance in lens fibre development ✅ Exp: Defects in lens fibres → cataract.
79. Congenital glaucoma (buphthalmos) due to:
A. Trabecular dysgenesis
B. Failure of optic fissure closure
C. Persistent pupillary membrane
D. Microcornea
View Answer
A. Trabecular dysgenesis ✅ Exp: Maldevelopment of trabecular meshwork.
80. Peter’s anomaly is due to:
A. Central corneal opacity + anterior segment dysgenesis
B. Foveal hypoplasia
C. Coloboma
D. Persistent hyaloid system
View Answer
A. Central corneal opacity + anterior segment dysgenesis ✅ Exp: Rare congenital anomaly involving cornea & anterior chamber.
These 40 MCQs (Q41–80) complete the Section 5: MCQ for Development of Eyeball series, covering critical aspects of eyelid, conjunctiva, lacrimal system, iris, ciliary body, lens, vitreous, postnatal development, and genetic control. Regular practice of these eye embryology MCQs is essential for NEET PG, AIIMS, B.Sc optometry, ophthalmic officers exam and other ophthalmology exams.
Stay tuned for more ophthalmology MCQ series covering detailed topics in eye anatomy and clinical correlations. Don’t forget to review previous batches to strengthen your understanding of the complete development of the eyeball.
