Explore 40 important Mcq bank of eyeball Development Milestones covering embryonic, fetal, and postnatal stages. Learn key timelines like optic cup and lens formation, hyaloid artery regression, retinal differentiation, eyelid fusion, foveal and optic nerve maturation, and visual acuity development. Perfect for ophthalmology students, NEET PG, and medical entrance exam preparation. visit our index page to topic wise ophthalmology mcq.

1. Eye development begins during:
A. 2nd week
B. 3rd week
C. 4th week
D. 5th week

View Answer

B. 3rd week ✅ Exp: Optic vesicle appears in week 3.

2. Lens placode forms in:
A. 3rd week
B. 4th week
C. 6th week
D. 8th week

View Answer

B. 4th week ✅ Exp: Surface ectoderm thickens at week 4.

3. Optic cup forms from:
A. Evagination of diencephalon
B. Mesenchyme
C. Neural crest only
D. Surface ectoderm

View Answer

A. Evagination of diencephalon ✅ Exp: Optic vesicle → optic cup.

4. Embryonic (fetal) fissure appears to allow entry of:
A. Hyaloid artery
B. Optic nerve
C. Lacrimal duct
D. Vitreous humor

View Answer

A. Hyaloid artery ✅ Exp: Fissure allows hyaloid artery to enter.

5. Closure of embryonic fissure occurs in:
A. 4th week
B. 5th–6th week
C. 8th week
D. Birth

View Answer

B. 5th–6th week ✅ Exp: By 6th week fissure closes.

6. Failure of fissure closure leads to:
A. Coloboma
B. Aniridia
C. Albinism
D. Aphakia

View Answer

A. Coloboma ✅ Exp: Typical coloboma occurs inferiorly.

7. Primary vitreous forms during:
A. 3rd–4th week
B. 6th week
C. 8th week
D. Birth

View Answer

A. 3rd–4th week ✅ Exp: Early vitreous with hyaloid artery.

8. Retinal pigment epithelium differentiation starts at:
A. 5th week
B. 8th week
C. Birth
D. 2nd month

View Answer

A. 5th week ✅ Exp: RPE forms from outer optic cup by week 5.

9. Neural retina layers begin forming in:
A. 6th week
B. 3rd week
C. 12th week
D. Postnatally

View Answer

A. 6th week ✅ Exp: Differentiation begins ~6 weeks.

10. Choroidal vasculature begins development at:
A. 6th week
B. 8th week
C. 10th week
D. Birth

View Answer

A. 6th week ✅ Exp: Mesenchyme forms vascular choroid early.

Fetal Stage (Weeks 9–Birth)

11. Corneal stroma differentiation begins:
A. 6th week
B. 7th week
C. 10th week
D. Birth

View Answer

B. 7th week ✅ Exp: From neural crest mesenchyme.

12. Lens fibres elongate to fill lens vesicle in:
A. 7th week
B. 4th week
C. 12th week
D. Birth

View Answer

A. 7th week ✅ Exp: Primary lens fibres fill vesicle.

13. Hyaloid vascular system peaks at:
A. 9th week
B. 4th week
C. BirthD. 3rd month postnatal

View Answer

A. 9th week ✅ Exp: Fully developed by ~9 weeks.

14. Eyelids fuse at:
A. 2nd month (8 weeks)
B. 4th month
C. 6th month
D. Birth

View Answer

A. 2nd month (8 weeks) ✅ Exp: Fusion protects developing cornea.

15. Eyelid separation occurs at:
A. 5th month
B. 6th month
C. Birth
D. 2nd month

View Answer

B. 6th month ✅ Exp: Lids reopen at ~6 months gestation.

16. Pupillary membrane develops from:
A. Mesodermal mesenchyme
B. Surface ectoderm
C. Neural crest
D. Neuroectoderm

View Answer

A. Mesodermal mesenchyme ✅ Exp: Temporary vascular membrane in front of lens.

17. Pupillary membrane regresses by:
A. 7th month
B. 8th month
C. Birth
D. 1 year

View Answer

B. 8th month ✅ Exp: Normally disappears by month 8.

18. Persistence of pupillary membrane leads to:
A. Strands across pupil
B. Coloboma
C. Microphthalmia
D. Glaucoma

View Answer

A. Strands across pupil ✅ Exp: Fine strands may remain.

19. Iris muscles (sphincter/dilator pupillae) differentiate in:
A. 3rd month
B. Birth
C. 6th month
D. Postnatal

View Answer

A. 3rd month ✅ Exp: Neuroectoderm-derived smooth muscle.

20. Canal of Schlemm develops by:
A. 4th month
B. Birth
C. 1 year
D. 6 months postnatal

View Answer

A. 4th month ✅ Exp: Forms from mesenchyme ~4th month.

Postnatal Development

21. Lacrimal gland becomes functional at:
A. Birth
B. 3rd month after birth
C. 6th month
D. 1 year

View Answer

B. 3rd month after birth ✅ Exp: Tears appear after ~3 months.

22. Pupillary light reflex appears:
A. Birth
B. ~30 weeks gestation
C. 12 weeks
D. 6 months

View Answer

B. ~30 weeks gestation ✅ Exp: Detectable in fetus by 30 weeks.

23. Myelination of optic nerve completed by:
A. Birth
B. 1 year
C. 3 years
D. 6 months

View Answer

B. 1 year ✅ Exp: Progresses from LGN → stops at lamina cribrosa.

24. Foveal pit matures by:
A. 6 months
B. 4 years
C. 2 years
D. Birth

View Answer

B. 4 years ✅ Exp: Fovea fully mature ~4 years.

25. Eyeball reaches adult size at:
A. Birth
B. 7–8 years
C. 12 years
D. Adolescence

View Answer

B. 7–8 years ✅ Exp: Most growth complete by 7–8 years.

26. Corneal diameter at birth:
A. 8 mm
B. 10 mm
C. 12 mm
D. 14 mm

View Answer

B. 10 mm ✅ Exp: Adult size ~11–12 mm.

27. Corneal transparency depends on:
A. Regular stromal arrangement
B. Thick epithelium
C. Pigment in stroma
D. Lens clarity

View Answer

A. Regular stromal arrangement ✅ Exp: Uniform collagen spacing crucial.

28. Visual acuity at birth is approx:
A. 6/60
B. 6/6
C. 6/24
D. Counting fingers only

View Answer

A. 6/60 ✅ Exp: Poor acuity at birth; improves gradually.

29. Visual acuity becomes near-adult at:
A. 1 year
B. 3–4 years
C. 6 months
D. Birth

View Answer

B. 3–4 years ✅ Exp: Parallel to foveal maturation.

30. Tear production sufficient for crying (“crocodile tears”) by:
A. 3 months
B. Birth
C. 1 year
D. 6 months

View Answer

A. 3 months ✅ Exp: Functional lacrimal gland at ~3 months.

Embryonic Milestones

31. Lens vesicle fully separates from surface ectoderm at:
A. 4th week
B. 5th week
C. 8th week
D. Birth

View Answer

B. 5th week ✅ Exp: Separation occurs by week 5.

32. Primary lens fibres elongate and fill cavity by:
A. 7th week
B. 10th week
C. 12th week
D. 4th month

View Answer

A. 7th week ✅ Exp: They fill vesicle during week 7.

33. Secondary lens fibres start forming at:
A. End of 7th week
B. Birth
C. 1 year
D. 12th week

View Answer

A. End of 7th week ✅ Exp: Secondary fibres form lens cortex.

34. Hyaloid artery is most active in:
A. 10th week
B. 20th week
C. Birth
D. 1 year

View Answer

A. 10th week ✅ Exp: Hyaloid system nourishes developing lens early.

35. Regression of hyaloid artery usually complete by:
A. Birth
B. 6 months
C. 3 months
D. 1 year

View Answer

A. Birth ✅ Exp: Normally gone before birth.

36. Failure of hyaloid regression causes:
A. Persistent hyperplastic primary vitreous (PHPV)
B. Coloboma
C. Aniridia
D. Aphakia

View Answer

A. Persistent hyperplastic primary vitreous (PHPV) ✅ Exp: PHPV → fibrovascular tissue persists.

37. Neural retina begins differentiation at:
A. 6th week
B. Birth
C. 12th week
D. 4th month

View Answer

A. 6th week ✅ Exp: Early formation of nuclear/ganglion layers.

38. Optic nerve fibres start forming by:
A. 8th week
B. Birth
C. 4th week
D. 6th month

View Answer

A. 8th week ✅ Exp: Axons from ganglion cells extend into optic stalk.

39. Ganglion cells of retina appear at:
A. 8th week
B. 12th week
C. 20th week
D. Birth

View Answer

A. 8th week ✅ Exp: Earliest neuronal layer to appear.

40. Photoreceptors differentiate significantly by:
A. 4th month
B. Birth
C. 6 months
D. 8th week

View Answer

A. 4th month ✅ Exp: Outer nuclear layer matures in mid-gestation.